Thymidine

Product Name: Thymidine
CAS No.: 50-89-5
Chemical Name: Thymidine
Synonyms: DT;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione;Deoxythymidine;β-Thymidine;b-Thymidine;Thymidin;Deoxyribothymidine;-Methylvalerophenone;THYMINE-2-DEOXYRIBOSIDE;Tyrosinase-related protein 2
CBNumber: CB6134417
Molecular Formula: C10H14N2O5
Formula Weight: 242.23
MOL File: 50-89-5.mol

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Thymidine Property

Melting point:: 186-188 °C(lit.)
alpha: 18.6 º (c=3, H2O)
Boiling point:: 385.05°C (rough estimate)
Density: 1.3129 (rough estimate)
refractive index: 33 ° (C=1, 1mol/L NaOH)
storage temp.: 2-8°C
solubility: Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P
pka: pK1:9.79;pK2:12.85 (25°C)
form: Crystalline Powder
color: White to almost white
optical activity: [α]20/D +19±1°, c = 1% in H2O
Water Solubility: SOLUBLE
Merck: 14,9397
BRN: 89285
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: IQFYYKKMVGJFEH-XLPZGREQSA-N
LogP: -0.930
CAS DataBase Reference: 50-89-5(CAS DataBase Reference)
NIST Chemistry Reference: Thymidine(50-89-5)
EPA Substance Registry System: Thymidine (50-89-5)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-40-36/37/38-68
Safety Statements: 22-24/25-37/39-26-36/37/39
WGK Germany: 3
RTECS: XP2071000
F: 10
TSCA: Yes
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 89270
Product name: Thymidine
Purity: ≥99.0% (HPLC)
Packaging: 1g
Price: $57.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3163
Product name: Zidovudine Related Compound D
Purity: pharmaceutical secondary standard
Packaging: 100MG
Price: $534
Updated: 2024/03/01

Sigma-Aldrich

Product number: 6060
Product name: Thymidine - CAS 50-89-5 - Calbiochem
Packaging: 5G
Price: $82.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1724543
Product name: Zidovudine Related Compound D
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $1180
Updated: 2024/03/01

TCI Chemical

Product number: T0233
Product name: Thymidine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $31
Updated: 2024/03/01

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Thymidine Chemical Properties,Usage,Production

Description

Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G₁/early S phase.

Chemical Properties

White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents.

Physical properties

Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside.

Uses

Constituent of deoxyribonucleic acid. The nucleoside (deoxyriboside) of thymine. Occurs in DNA. It is a nucleoside consisting of one thymine molecule linked to ad-doxyribose sugar molecule.

Uses

Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology.

Definition

The NUCLEOSIDE formed when thymine is linked to D-ribose by a β-glycosidic bond.

Definition

ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine.

General Description

Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine.

Biochem/physiol Actions

Thymidine is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.

Mechanism of action

High concentrations of thymidine interrupt the deoxynucleotide metabolism pathway through competitive inhibition, thus blocking DNA replication. A single treatment with thymidine arrests cells throughout S phase, so a double treatment acts to induce a more uniform block in early S phase.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH).

Thymidine Preparation Products And Raw materials

Raw materials

Preparation Products

Zidovudine Stavudine

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Thymidine Suppliers

Austria 1 Belgium 1 Canada 2 China 576 Europe 2 France 1 Germany 10 India 21 Japan 5 Russia 1 Singapore 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 16 United States 73 Global 715

HBCChem, Inc.

Tel: +1-510-219-6317
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Country: United States
ProdList: 10658
Advantage: 60

EMMX Biotechnology LLC

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Country: United States
ProdList: 8449
Advantage: 60

AbaChemScene

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Alfa Chemistry

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Email: Info@alfa-chemistry.com
Country: United States
ProdList: 21317
Advantage: 58

InvivoChem

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Country: United States
ProdList: 6393
Advantage: 58

Accela ChemBio Inc.

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Fax: (+1)-858-876-1948
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Country: United States
ProdList: 19965
Advantage: 58

BOC Sciences

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Country: United States
ProdList: 19553
Advantage: 58

Cato Research Chemicals Inc.

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Alchem Pharmtech,Inc.

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Protheragen-ING

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Aladdin Scientific

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Aceschem Inc.

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View Lastest Price from Thymidine manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Thymidine 50-89-5
Price: US $5.00/kg
Min. Order: 1kg
Purity: 99.92%
Supply Ability: 50000tons
Release date: 2024-04-23

Yunbio Tech Co.,Ltd.

Product: Thymidine 50-89-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20ton
Release date: 2022-02-25

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Thymidine 50-89-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-09

50-89-5, ThymidineRelated Search:

Starch soluble Thymine 5-HYDROXYMETHYL-2'-DEOXYURIDINE T-SUCCINATE5'-O-DMTR-THYMIDINE-SUCCINATE 5’-o-[bis(4-methoxyphenyl)phenylmethyl]-thymidi THYMIDINE 5'-TRIPHOSPHATE SODIUM SALT,THYMIDINE-5'-TRIPHOSPHATE TETRASODIUM SALT,THYMIDINE-5'-TRIPHOSPHATE TRISODIUM SALT 3’-azido-3’-deoxy-thymidi Trifluridine DMT-dT Phosphoramidite 5-Methyluridine 5’-o-(triphenylmethyl)-thymidi Thymidine-5'-monophosphate disodium salt 3’-deoxy-thymidi Deoxythymidine triphosphate 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione 3’-deoxy-3’-fluoro-thymidi 2’,3’-didehydro-3’-deoxy-thymidi THYMIDINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-5-methyl-

-Nerve Growth Factor (NGF), Induction of neurite outgrowth in PC12 cells, Human recombinant, 27kD

SS-THYMIDINE

1-(2-Deoxy-β-D-ribofuranosy

ThymidineForBiochemistry

ThymidineForBiochemistry-(ThymineDeoxyriboside)

b-Thymidine

Thymidine,>96%

1-(2-Deoxy-b-D-ribofuranosyl)-5-methyluracil

-THYMIDINE (Thymine-2’-deoxyriboside)

THYMIDINE,REAGENT,HIGHPURITY

THYMIDIN(RG)

Thymidine synthetic

β-THYMIDINE (2''-DEOXYTHYMIDINE )

THYMIDINE extrapure

1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil, 1-(2-Deoxy-β-D-ribofuranosyl)thymine, 2μ-Deoxythymidine, dT, Thymine deoxyriboside

1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Deoxyribothymidine

Benzenepropanoic acid, Beta-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-

B-THYMIDINE (Thymine-2’-deoxyriboside)

1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

DNA,SALT,FISH SPERM

1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-furan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-

Thymine-2-deoxyriboside (1-[2-Deoxy-beta-D-ribofuranosyl]-5-methyluracil)

Zidovudine USP RC D

Zidovudine impurity E

2-Desoxy-thymidine

5-Methyldeoxyurindine

beta-D-Ribofuranoside, thymine-1 2-deoxy-

Deoxythymidin

Deoxythymidine

Desoxy-thymidin

Dthyd

Thymidin

Thymidine, 2'-deoxy-

URIDINE, 2'-DEOXY-5-METHYL-

THYMINE DEOXYRIBOSIDE

THYMINE-2'-DEOXYRIBOSIDE

THYMINE-2-DEOXYRIBOSIDE

THYMINE 2-DESOXYRIBOSIDE

THYMIDINE

2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)-5-METHYL-

2'-DEOXYRIBOSYLTHYMINE

2'-DEOXYTHYMIDINE

5-METHYLDEOXYURIDINE

5-METHYL-2'-DEOXYURIDINE

1-[2-DEOXY-BETA-D-RIBOFURANOSYL]-5-METHYLURACIL

1-[2-DEOXY-BETA-D-RIBOFURANOSYL]-5-METHYLURACYL

1-(2-DEOXY-BETA -D-ERYTHRO-PENTOFURANOSYL)-5-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE

1-(2-DEOXY-BETA-D-RIBOFURANOSYL)THYMINE

1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-PYRIMIDINE-2,4-DIONE

DT

DTHD

E-D-RIBOFURANOSIDE, THYMINE-1 2-DEOXY-

1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil

1-(2-Deoxy-β-D-ribofuranosyl)thymine